InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc26a8

Summary

InnateDB Protein

IDBP-251073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc26a8

Protein Name

solute carrier family 26, member 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110412

InnateDB Gene

IDBG-158850 (Slc26a8)

Protein Structure

UniProt Annotation

Function

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involvrd in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:17517695}; Multi-pass membrane protein {ECO:0000269PubMed:17517695}. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269PubMed:17517695}.

Disease Associations

Tissue Specificity

Expressed in testis and epididymis. Located at the end of the midpiece of the flagella, known as the annulus, in spermatozoa. {ECO:0000269PubMed:17517695}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0019531	oxalate transmembrane transporter activity

Biological Process

GO:0006820	anion transport
GO:0006821	chloride transport
GO:0007126	meiotic nuclear division
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008272	sulfate transport
GO:0019532	oxalate transport
GO:0030154	cell differentiation
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport