InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapk14

Summary

InnateDB Protein

IDBP-251088.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Mapk14

Protein Name

mitogen-activated protein kinase 14

Synonyms

Crk1; Csbp1; CSBP2; Mxi2; p38; p38-alpha; p38a; p38alpha; p38MAPK; PRKM14; PRKM15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110406

InnateDB Gene

IDBG-158983 (Mapk14)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	67 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000165	MAPK cascade
GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0002062	chondrocyte differentiation
GO:0006006	glucose metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007519	skeletal muscle tissue development
GO:0009103	lipopolysaccharide biosynthetic process
GO:0014835	myoblast differentiation involved in skeletal muscle regeneration
GO:0018105	peptidyl-serine phosphorylation
GO:0019395	fatty acid oxidation
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032495	response to muramyl dipeptide
GO:0032496	response to lipopolysaccharide
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0042307	positive regulation of protein import into nucleus
GO:0042770	signal transduction in response to DNA damage
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0051146	striated muscle cell differentiation
GO:0071222	cellular response to lipopolysaccharide
GO:0071479	cellular response to ionizing radiation
GO:0090400	stress-induced premature senescence
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000922	spindle pole
GO:0005623	cell
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1346865

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR008352 Mitogen-activated protein (MAP) kinase, p38
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109
PR01773

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt