InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL9

Summary

InnateDB Protein

IDBP-25113.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL9

Protein Name

chemokine (C-X-C motif) ligand 9

Synonyms

CMK; crg-10; Humig; MIG; SCYB9;

Species

Homo sapiens

Ensembl Protein

ENSP00000354901

InnateDB Gene

IDBG-25111 (CXCL9)

Protein Structure

UniProt Annotation

Function

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0060326	cell chemotaxis