InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacnb2

Summary

InnateDB Protein

IDBP-251167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacnb2

Protein Name

calcium channel, voltage-dependent, beta 2 subunit

Synonyms

AW060387; CAB2; Cavbeta2; Cchb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110367

InnateDB Gene

IDBG-138441 (Cacnb2)

Protein Structure

UniProt Annotation

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000250}.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0034765	regulation of ion transmembrane transport
GO:0051928	positive regulation of calcium ion transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

MGI:894644

InterPro

IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF12052
PF00018
PF14604
PF00625

PRINTS

PR01626
PR00452
PR01628

PIRSF

SMART

SM00326
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt