InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCTD13

Summary

InnateDB Protein

IDBP-25134.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCTD13

Protein Name

potassium channel tetramerisation domain containing 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000311202

InnateDB Gene

IDBG-25132 (KCTD13)

Protein Structure

UniProt Annotation

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. {ECO:0000269PubMed:19782033}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11593007}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues. {ECO:0000269PubMed:11593007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0017049	GTP-Rho binding

Biological Process

GO:0006260	DNA replication
GO:0016477	cell migration
GO:0016567	protein ubiquitination
GO:0035024	negative regulation of Rho protein signal transduction
GO:0043149	stress fiber assembly
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260	protein homooligomerization