InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmprss7

Summary

InnateDB Protein

IDBP-251499.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmprss7

Protein Name

transmembrane serine protease 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110209

InnateDB Gene

IDBG-163310 (Tmprss7)

Protein Structure

UniProt Annotation

Function

Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position. {ECO:0000269PubMed:15853774}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15853774}; Single-pass type II membrane protein {ECO:0000269PubMed:15853774}.

Disease Associations

Tissue Specificity

Expressed in brain, eye, testis, skin, epididymis and salivary gland with lower levels in heart, skeletal muscle, thymus, ovary, prostate and uterus. {ECO:0000269PubMed:15853774}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2686594

InterPro

IPR000082 SEA domain
IPR000859 CUB domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF01390
PF00431
PF00089
PF00057

PRINTS

PR00722
PR00261

PIRSF

SMART

SM00200
SM00042
SM00020
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt