Version 5.4
Mus musculus Protein: Zfp467
Summary
InnateDB Protein IDBP-251509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp467
Protein Name zinc finger protein 467
Synonyms 1190001I08Rik; AB041616; AI426952; AV017623; EZI; Znf467;
Species Mus musculus
Ensembl Protein ENSMUSP00000110207
InnateDB Gene IDBG-144418 (Zfp467)
Protein Structure
UniProt Annotation
Function Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex. {ECO:0000269PubMed:12426389, ECO:0000269PubMed:21123171}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12426389}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1916160
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZL0
PhosphoSite PhosphoSite-Q8JZL0
TrEMBL B2RU53
UniProt Splice Variant
Entrez Gene 68910
UniGene Mm.2464
RefSeq NP_001078884
MGI ID
MGI Symbol Zfp467
OMIM
CCDS CCDS51764
HPRD
IMGT
EMBL AB041616 AB076746 AK033146 BC029859 BC140975 CH466597
GenPept AAH29859 AAI40976 BAA95099 BAC00997 BAC28171 EDK98529 EDK98530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca