Homo sapiens Protein: TAOK2 | |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-25153.7 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | TAOK2 | ||||||||||||||||||||||||||||||
Protein Name | TAO kinase 2 | ||||||||||||||||||||||||||||||
Synonyms | MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2; | ||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000279394 | ||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-25151 (TAOK2) | ||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||
Function | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269PubMed:10660600, ECO:0000269PubMed:11279118, ECO:0000269PubMed:12639963, ECO:0000269PubMed:12665513, ECO:0000269PubMed:13679851, ECO:0000269PubMed:16893890, ECO:0000269PubMed:17158878, ECO:0000269PubMed:17396146}. | ||||||||||||||||||||||||||||||
Subcellular Localization | Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full- length isoform 1 are excluded from the nucleus.Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}. | ||||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed, with a higher level of expression in testis and brain. {ECO:0000269PubMed:10660600, ECO:0000269PubMed:13679851}. | ||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
|
||||||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR009057 Homeodomain-like IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
||||||||||||||||||||||||||||||
PFAM |
PF00069
PF07714 |
||||||||||||||||||||||||||||||
PRINTS |
PR00109
|
||||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||||
SMART |
SM00220
SM00219 |
||||||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||
SwissProt | Q9UL54 | ||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UL54 | ||||||||||||||||||||||||||||||
TrEMBL | B4E2V3 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 9344 | ||||||||||||||||||||||||||||||
UniGene | Hs.291623 | ||||||||||||||||||||||||||||||
RefSeq | NP_004774 | ||||||||||||||||||||||||||||||
HUGO | HGNC:16835 | ||||||||||||||||||||||||||||||
OMIM | 613199 | ||||||||||||||||||||||||||||||
CCDS | CCDS10662 | ||||||||||||||||||||||||||||||
HPRD | 18147 | ||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | AB020688 AC093512 AF061943 AF263313 AK291473 AK304446 AL137701 AY358942 BC136653 BC136655 BC142663 BC144344 BC151221 BC152413 CH471238 | ||||||||||||||||||||||||||||||
GenPept | AAD45616 AAG38503 AAI36654 AAI36656 AAI42664 AAI44345 AAI51222 AAI52414 AAQ89301 BAA74904 BAF84162 BAG65265 CAB70882 EAW79963 EAW79964 | ||||||||||||||||||||||||||||||