InnateDB Protein
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IDBP-251590.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Bre
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Protein Name
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brain and reproductive organ-expressed protein
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Synonyms
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6030405P19Rik; AI429776; B830038C02Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110152
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InnateDB Gene
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IDBG-150391 (Bre)
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Protein Structure
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Function |
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity). May regulate TNF-alpha signaling through its interactions with TNFRSF1A. {ECO:0000250, ECO:0000269PubMed:9737713}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double- strand breaks (DSBs). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, testis, germinal center B-cells and various mouse cell lines. {ECO:0000269PubMed:11676476, ECO:0000269PubMed:14565866}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
42 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005164
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tumor necrosis factor receptor binding
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GO:0031593
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polyubiquitin binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333875
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InterPro |
IPR010358
Brain/reproductive organ-expressed protein
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PFAM |
PF06113
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K3W0
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PhosphoSite |
PhosphoSite-Q8K3W0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
107976
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UniGene |
Mm.482126
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RefSeq |
NP_851798
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MGI ID |
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MGI Symbol |
Bre
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OMIM |
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CCDS |
CCDS51461
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HPRD |
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IMGT |
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EMBL |
AF440752
AF527952
AF527953
AF527954
AF527955
AF538925
AK050695
AK080991
AK156929
BC061000
BC100565
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GenPept |
AAH61000
AAI00566
AAL40809
AAM92774
AAM92775
AAM92776
AAM92777
AAN15148
BAC34385
BAC38108
BAE33900
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