InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il1rn

Summary

InnateDB Protein

IDBP-251670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il1rn

Protein Name

interleukin 1 receptor antagonist

Synonyms

F630041P17Rik; IL-1ra;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110131

InnateDB Gene

IDBG-142372 (Il1rn)

Protein Structure

UniProt Annotation

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

Subcellular Localization

Isoform 1: Secreted.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005150	interleukin-1, Type I receptor binding
GO:0005151	interleukin-1, Type II receptor binding
GO:0045352	interleukin-1 Type I receptor antagonist activity
GO:0045353	interleukin-1 Type II receptor antagonist activity

Biological Process

GO:0001660	fever generation
GO:0002439	chronic inflammatory response to antigenic stimulus
GO:0006629	lipid metabolic process
GO:0007565	female pregnancy
GO:0007613	memory
GO:0010243	response to organonitrogen compound
GO:0014050	negative regulation of glutamate secretion
GO:0019752	carboxylic acid metabolic process
GO:0030073	insulin secretion
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0045837	negative regulation of membrane potential
GO:0051384	response to glucocorticoid
GO:0070670	response to interleukin-4
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0031982	vesicle

Protein Structure and Domains

PDB ID

MGI:96547

InterPro

IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR008996 Cytokine, IL-1-like

PFAM

PF00340

PRINTS

PR00264
PR01357
PR01360

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25085