InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnck

Summary

InnateDB Protein

IDBP-251689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnck

Protein Name

pregnancy upregulated non-ubiquitously expressed CaM kinase

Synonyms

Bstk3; Camk1b; CaMKIbeta2; caMKlb1; CaMKlb2; Punc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110116

InnateDB Gene

IDBG-153170 (Pnck)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10537072}. Nucleus {ECO:0000269PubMed:10537072}.

Disease Associations

Tissue Specificity

Expressed at highest levels in adult brain, and expressed in embryo. In the adult brain detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentate granule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. Expressed at lower levels in adult ovary and heart and at very low levels in testis, lung and muscle. {ECO:0000269PubMed:10537072, ECO:0000269PubMed:10673339}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005954	calcium- and calmodulin-dependent protein kinase complex

Protein Structure and Domains

PDB ID

MGI:1347357

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt