InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 1600029D21Rik

Summary

InnateDB Protein

IDBP-251692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1600029D21Rik

Protein Name

RIKEN cDNA 1600029D21 gene

Synonyms

0610037B23Rik; 1600029D21Rik; AA407923; AU043048;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110118

InnateDB Gene

IDBG-163268 (1600029D21Rik)

Protein Structure

UniProt Annotation

Function

Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. {ECO:0000269PubMed:20130590}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:20130590}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:20130590}. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.

Disease Associations

Tissue Specificity

Present in hair follicle cells and sebaceous gland of skin, ciliated epithelial cells of trachea and bronchial tube, striated portion of submandibular gland, distal convoluted tubule cells of kidney, ciliated epithelial cells of oviduct, medulla of adrenal gland and anterior lobe of pituitary gland. Expressed in keratinocytes of the hair follicle at the trichilemmal zone corresponding to the terminally differentiated outermost suprabasal outer root sheath (ORS), including that of the sebaceous gland duct (SGD) and the directly adjacent upper distal end of the companion layer (CL). Expression is similar in all hair follicle growth stages. Also detected during both the early and late anagen phases above the bulge of stem cells. Expressed at the leading edge of the epidermal wound. Not expressed in the interfollicular epidermis (IFE), inner root sheath (IRS) and hair fiber. Highly expressed in placenta. Detected in mammary and prostate epithelia and in the pancreas (at protein level). {ECO:0000269PubMed:15203209, ECO:0000269PubMed:16219980, ECO:0000269PubMed:18195351, ECO:0000269PubMed:20130590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0035313	wound healing, spreading of epidermal cells