InnateDB Protein
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IDBP-251939.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kifc1
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Protein Name
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kinesin family member C1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110001
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InnateDB Gene
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IDBG-251935 (Kifc1)
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Protein Structure
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Function |
Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Early endosome {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:17360972}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in E14 embryos, spleen and NIH3T3 cells. Also expressed in testis, brain, lung, kidney and cultured astrocytes. Very low levels in skeletal muscle and heart. {ECO:0000269PubMed:16638812, ECO:0000269PubMed:9115736}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109596
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QWT9
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PhosphoSite |
PhosphoSite-Q9QWT9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100502766
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UniGene |
Mm.335713
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RefSeq |
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MGI ID |
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MGI Symbol |
Kifc1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF013117
AF110520
AF221102
AK081484
AM051187
BC003753
BC057162
BC100328
D49544
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GenPept |
AAC39966
AAC97970
AAF34646
AAH03753
AAH57162
AAI00329
BAA19676
BAC38230
CAJ19646
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