InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: St3gal6

Summary

InnateDB Protein

IDBP-251947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

St3gal6

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Synonyms

1700023B24Rik; AI930218; AW552396; Siat10; St3galVI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109997

InnateDB Gene

IDBG-168928 (St3gal6)

Protein Structure

UniProt Annotation

Function

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008373	sialyltransferase activity
GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006664	glycolipid metabolic process
GO:0009311	oligosaccharide metabolic process
GO:0071354	cellular response to interleukin-6
GO:0097503	sialylation