InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mfsd10

Summary

InnateDB Protein

IDBP-251999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfsd10

Protein Name

major facilitator superfamily domain containing 10

Synonyms

0610009O03Rik; Tetran;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109968

InnateDB Gene

IDBG-155611 (Mfsd10)

Protein Structure

UniProt Annotation

Function

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity). {ECO:0000250UniProtKB:Q14728}.

Subcellular Localization

Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006915	apoptotic process
GO:0055085	transmembrane transport

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1915544

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D2V8

PhosphoSite