Version 5.4
| Mus musculus Protein: Samsn1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-252184.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Samsn1 | ||||||||
| Protein Name | SAM domain, SH3 domain and nuclear localization signals, 1 | ||||||||
| Synonyms | 4930571B16Rik; 930571B16Rik; Hacs1; SLy2; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000109877 | ||||||||
| InnateDB Gene | IDBG-171448 (Samsn1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. {ECO:0000269PubMed:15381729, ECO:0000269PubMed:19923443, ECO:0000269PubMed:20478393, ECO:0000269PubMed:21296879}. | ||||||||
| Subcellular Localization | Nucleus. Cytoplasm. Cell projection, ruffle. Note=Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Detected in spleen and lymph node (at protein level). {ECO:0000269PubMed:15381729}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1914992 | ||||||||
| InterPro |
IPR001452
SH3 domain IPR001660 Sterile alpha motif domain IPR011510 Sterile alpha motif, type 2 IPR011511 Variant SH3 domain IPR013761 Sterile alpha motif/pointed domain IPR021090 SAM/SH3 domain-containing IPR021129 Sterile alpha motif, type 1 |
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| PFAM |
PF00018
PF14604 PF07647 PF07653 PF12485 PF00536 |
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| PRINTS |
PR00452
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| PIRSF | |||||||||
| SMART |
SM00326
SM00454 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P57725 | ||||||||
| PhosphoSite | PhosphoSite-P57725 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 67742 | ||||||||
| UniGene | Mm.473571 | ||||||||
| RefSeq | NP_075869 | ||||||||
| MGI ID | 1V38 | ||||||||
| MGI Symbol | Samsn1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS37378 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF222928 AK053946 BC052906 BC064778 DQ333189 | ||||||||
| GenPept | AAG23356 AAH52906 AAH64778 ABC59720 BAC35601 | ||||||||