InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPA1

Summary

InnateDB Protein

IDBP-25220.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPA1

Protein Name

transient receptor potential cation channel, subfamily A, member 1

Synonyms

ANKTM1; FEPS;

Species

Homo sapiens

Ensembl Protein

ENSP00000262209

InnateDB Gene

IDBG-25218 (TRPA1)

Protein Structure

UniProt Annotation

Function

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. {ECO:0000269PubMed:20547126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269PubMed:10066796}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0009409	response to cold
GO:0034220	ion transmembrane transport
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0048265	response to pain
GO:0050955	thermoception
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0050968	detection of chemical stimulus involved in sensory perception of pain
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport