InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jam2

Summary

InnateDB Protein

IDBP-252274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jam2

Protein Name

junction adhesion molecule 2

Synonyms

1110002N23Rik; 2410030G21Rik; 2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109833

InnateDB Gene

IDBG-172706 (Jam2)

Protein Structure

UniProt Annotation

Function

May play a role in the processes of lymphocyte homing to secondary lymphoid organs. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:11036763}. Cell membrane {ECO:0000269PubMed:11036763}; Single-pass type I membrane protein {ECO:0000269PubMed:11036763}. Note=Localized at tight junctions of both epithelial and endothelial cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007162

negative regulation of cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1933820

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JI59