Version 5.4
Mus musculus Protein: Otop1
Summary
InnateDB Protein IDBP-252484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Otop1
Protein Name otopetrin 1
Synonyms A530025J20Rik; Otp1; tlt;
Species Mus musculus
Ensembl Protein ENSMUSP00000109734
InnateDB Gene IDBG-159889 (Otop1)
Protein Structure
UniProt Annotation
Function Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP. {ECO:0000269PubMed:12651873, ECO:0000269PubMed:17606897}.
Subcellular Localization Membrane; Multi-pass membrane protein. Secreted, extracellular space. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium.
Disease Associations
Tissue Specificity Detected in embryonic inner ear macular epithelia. Detected in thymus, heart, kidney, skin, adrenal gland and lactating mammary gland. {ECO:0000269PubMed:12651873}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009590 detection of gravity
GO:0031214 biomineral tissue development
GO:0042472 inner ear morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2388363
InterPro IPR004878 Otopetrin
PFAM PF03189
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80VM9
PhosphoSite PhosphoSite-Q80VM9
TrEMBL
UniProt Splice Variant
Entrez Gene 21906
UniGene Mm.204765
RefSeq NP_766297
MGI ID
MGI Symbol Otop1
OMIM
CCDS
HPRD
IMGT
EMBL AF548337 AK040792 AK041023 BK000650
GenPept AAO33824 BAC30704 BAC30785 DAA00897 DAA00898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca