InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Son

Summary

InnateDB Protein

IDBP-252613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Son

Protein Name

Son DNA binding protein

Synonyms

2900011L12Rik; AA409051; AU067731; C81487; mKIAA1019; nrebp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109670

InnateDB Gene

IDBG-176345 (Son)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3' (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression. {ECO:0000250, ECO:0000269PubMed:20876580}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:20876580}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0050733	RS domain binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000910	cytokinesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043066	negative regulation of apoptotic process
GO:0043484	regulation of RNA splicing
GO:0051726	regulation of cell cycle