InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lsm2

Summary

InnateDB Protein

IDBP-252690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lsm2

Protein Name

LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Synonyms

D17H6S56E-2; D17H6S56E2; Dmapl; Dmpkap; G7b; Sm-X5; SmX5; snRNP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109644

InnateDB Gene

IDBG-175385 (Lsm2)

Protein Structure

UniProt Annotation

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005681

spliceosomal complex

Protein Structure and Domains

PDB ID

MGI:90676

InterPro

IPR001163 Ribonucleoprotein LSM domain
IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920 Like-Sm (LSM) domain
IPR016654 U6 snRNA-associated Sm-like protein LSm2

PFAM

PF01423

PRINTS

PIRSF

PIRSF016394

SMART

SM00651

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt