InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dctn1

Summary

InnateDB Protein

IDBP-252852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctn1

Protein Name

dynactin 1

Synonyms

AL022633; Glued; p150; p150;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109552

InnateDB Gene

IDBG-160591 (Dctn1)

Protein Structure

UniProt Annotation

Function

Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0045502	dynein binding
GO:0048037	cofactor binding

Biological Process

GO:0008152	metabolic process
GO:0010970	microtubule-based transport
GO:0031122	cytoplasmic microtubule organization
GO:0032402	melanosome transport
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0031252	cell leading edge
GO:0043234	protein complex