InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fam123b

Summary

InnateDB Protein

IDBP-252975.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fam123b

Protein Name

family with sequence similarity 123, member B

Synonyms

2810002O09Rik; AW492303; Fam123b; Wtx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109502

InnateDB Gene

IDBG-215360 (Fam123b)

Protein Structure

UniProt Annotation

Function

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney. {ECO:0000269PubMed:17204608}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008013	beta-catenin binding

Biological Process

GO:0001822	kidney development
GO:0016055	Wnt signaling pathway
GO:0060348	bone development
GO:0060612	adipose tissue development
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0072161	mesenchymal cell differentiation involved in kidney development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway