Version 5.4
Mus musculus Protein: Las1l
Summary
InnateDB Protein IDBP-252981.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Las1l
Protein Name LAS1-like (S. cerevisiae)
Synonyms 1810030A06Rik; 5830482G23Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000109495
InnateDB Gene IDBG-160706 (Las1l)
Protein Structure
UniProt Annotation
Function Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000250, ECO:0000269PubMed:22872859}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269PubMed:22872859}. Cytoplasm {ECO:0000269PubMed:22872859}. Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006364 rRNA processing
GO:0008150 biological_process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID MGI:1923380
InterPro IPR007174 Las1-like
PFAM PF04031
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2BE28
PhosphoSite PhosphoSite-A2BE28
TrEMBL A9X413
UniProt Splice Variant
Entrez Gene 76130
UniGene Mm.274318
RefSeq XP_006528397
MGI ID
MGI Symbol Las1l
OMIM
CCDS
HPRD
IMGT
EMBL AK052578 AK131142 BC141155 BX005184 DQ323627
GenPept AAI41156 ABD39130 BAC35047 BAD21392 CAM25407 CAM25408

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca