InnateDB Protein
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IDBP-253053.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eda2r
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Protein Name
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ectodysplasin A2 receptor
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109463
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InnateDB Gene
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IDBG-161374 (Eda2r)
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Protein Structure
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Function |
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0007275
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multicellular organismal development
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GO:0012501
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programmed cell death
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GO:0030154
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cell differentiation
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GO:0046330
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positive regulation of JNK cascade
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0072332
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intrinsic apoptotic signaling pathway by p53 class mediator
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Cellular Component |
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PDB ID |
MGI:2442860
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR022319
Tumour necrosis factor receptor 27
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PFAM |
PF00020
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PRINTS |
PR01973
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PIRSF |
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BX35
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q3KP88
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UniProt Splice Variant |
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Entrez Gene |
245527
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UniGene |
Mm.189270
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RefSeq |
XP_006528088
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MGI ID |
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MGI Symbol |
Eda2r
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OMIM |
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CCDS |
CCDS30293
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HPRD |
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IMGT |
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EMBL |
AK034909
AK049134
BC106845
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GenPept |
AAI06846
BAC28879
BAC33562
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