Version 5.4
Mus musculus Protein: Tprkb
Summary
InnateDB Protein IDBP-253223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tprkb
Protein Name Tp53rk binding protein
Synonyms 0610033G21Rik; 1810034M08Rik; Cgi-121; DRWMS1; mDRWMS1;
Species Mus musculus
Ensembl Protein ENSMUSP00000109382
InnateDB Gene IDBG-164173 (Tprkb)
Protein Structure
UniProt Annotation
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019901 protein kinase binding
Biological Process
GO:0008033 tRNA processing
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1917036
InterPro IPR013926 CGI121/TPRKB
PFAM PF08617
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZZ7
PhosphoSite PhosphoSite-Q8QZZ7
TrEMBL D3Z5E8
UniProt Splice Variant
Entrez Gene 69786
UniGene Mm.218434
RefSeq NP_001163959
MGI ID
MGI Symbol Tprkb
OMIM
CCDS CCDS20305
HPRD
IMGT
EMBL AC158679 BC024858 BC027162
GenPept AAH24858 AAH27162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca