Version 5.4
Mus musculus Protein: Pin4
Summary
InnateDB Protein IDBP-253482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pin4
Protein Name protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
Synonyms 2410002I22Rik; EPVH; Par14;
Species Mus musculus
Ensembl Protein ENSMUSP00000109257
InnateDB Gene IDBG-253480 (Pin4)
Protein Structure
UniProt Annotation
Function Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003681 bent DNA binding
GO:0003690 double-stranded DNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006364 rRNA processing
GO:0006457 protein folding
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0030684 preribosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1916963
InterPro IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
PFAM PF00639
PF13145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CWW6
PhosphoSite PhosphoSite-Q9CWW6
TrEMBL
UniProt Splice Variant
Entrez Gene 69713
UniGene Mm.473066
RefSeq NP_081457
MGI ID
MGI Symbol Pin4
OMIM
CCDS CCDS41082
HPRD
IMGT
EMBL AK010338 AL807784 BC119355 BC119357 CH466564
GenPept AAI19356 AAI19358 BAB26863 CAM24632 EDL14129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca