InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phka1

Summary

InnateDB Protein

IDBP-253506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phka1

Protein Name

phosphorylase kinase alpha 1

Synonyms

5330411D17; 9830108K24Rik; Phka;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109241

InnateDB Gene

IDBG-165082 (Phka1)

Protein Structure

UniProt Annotation

Function

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Note=Defects in Phka1 are the cause of phosphorylase kinase deficiency in I-strain mice.

Tissue Specificity

Both isoforms are expressed in muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005516	calmodulin binding

Biological Process

GO:0005976	polysaccharide metabolic process
GO:0005977	glycogen metabolic process

Cellular Component

GO:0005886

plasma membrane

Protein Structure and Domains

PDB ID

MGI:97576

InterPro

IPR008928 Six-hairpin glycosidase-like
IPR011613 Glycoside hydrolase family 15

PFAM

PF00723

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18826

PhosphoSite

PhosphoSite-P18826

TrEMBL

Q8BSV5

UniProt Splice Variant

Entrez Gene

18679

UniGene

Mm.212889

RefSeq

MGI ID

MGI Symbol

Phka1

OMIM

CCDS

HPRD

IMGT

EMBL

AK030426 AL732405 AL805925 M28867 X73877 X74616

GenPept

AAA39927 BAC26957 CAA52085 CAA52687 CAM15410 CAM17599