InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TERF1

Summary

InnateDB Protein

IDBP-25351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TERF1

Protein Name

telomeric repeat binding factor (NIMA-interacting) 1

Synonyms

hTRF1-AS; PIN2; t-TRF1; TRBF1; TRF; TRF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000276603

InnateDB Gene

IDBG-25349 (TERF1)

Protein Structure

UniProt Annotation

Function

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269PubMed:16166375}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.

Disease Associations

Tissue Specificity

Highly expressed and ubiquitous. Isoform Pin2 predominates.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 330 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	331 [view]
Protein-Protein	327 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003691	double-stranded telomeric DNA binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008301	DNA binding, bending
GO:0042162	telomeric DNA binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000723	telomere maintenance
GO:0001309	age-dependent telomere shortening
GO:0007004	telomere maintenance via telomerase
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0008156	negative regulation of DNA replication
GO:0010834	telomere maintenance via telomere shortening
GO:0031116	positive regulation of microtubule polymerization
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0032214	negative regulation of telomere maintenance via semi-conservative replication
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045840	positive regulation of mitosis
GO:0045931	positive regulation of mitotic cell cycle
GO:0051260	protein homooligomerization
GO:0051974	negative regulation of telomerase activity

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle

Protein Structure and Domains

PDB ID

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR013867 Telomere repeat-binding factor, dimerisation domain
IPR017357 Telomeric repeat-binding factor 1/2
IPR017877 Myb-like domain

PFAM

PF00249
PF08558

PRINTS

PIRSF

PIRSF038016

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt