Mus musculus Protein: Rab7 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-253541.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Rab7 | ||||||||||||||||||||||||||
Protein Name | RAB7, member RAS oncogene family | ||||||||||||||||||||||||||
Synonyms | Rab7a; | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000109226 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-253533 (Rab7) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||||
Subcellular Localization | Late endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Melanosome {ECO:0000250}. Note=Co-localizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | Widely expressed. High expression in liver, heart and kidney. Found in sensory and motor neurons. {ECO:0000269PubMed:12545426}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | MGI:105068 | ||||||||||||||||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR001806 Small GTPase superfamily IPR002041 Ran GTPase IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR006762 Gtr1/RagA G protein IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
||||||||||||||||||||||||||
PFAM |
PF00009
PF00071 PF00025 PF04670 PF08477 |
||||||||||||||||||||||||||
PRINTS |
PR00315
PR00449 PR00627 PR00328 |
||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART |
SM00176
SM00174 SM00175 SM00173 |
||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | P51150 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P51150 | ||||||||||||||||||||||||||
TrEMBL | Q4FJQ0 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 19349 | ||||||||||||||||||||||||||
UniGene | Mm.333233 | ||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | Rab7 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS39552 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AB232599 AK005004 AK139914 AK148117 AK151078 AK152666 AK154234 AK158971 AK159928 BC004597 BC086793 CH466523 CT010352 X89650 | ||||||||||||||||||||||||||
GenPept | AAH04597 AAH86793 BAB23738 BAE24180 BAE28355 BAE30093 BAE31401 BAE32452 BAE34750 BAE35490 BAF02861 CAA61797 CAJ18560 EDK99239 | ||||||||||||||||||||||||||