Version 5.4
Mus musculus Protein: Tmem198
Summary
InnateDB Protein IDBP-253597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem198
Protein Name transmembrane protein 198
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000109205
InnateDB Gene IDBG-171465 (Tmem198)
Protein Structure
UniProt Annotation
Function Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Largely located to vesicle-like structures. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:2443133
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BG75
PhosphoSite PhosphoSite-Q8BG75
TrEMBL
UniProt Splice Variant
Entrez Gene 319998
UniGene Mm.44401
RefSeq NP_796030
MGI ID
MGI Symbol Tmem198
OMIM
CCDS CCDS15076
HPRD
IMGT
EMBL AK038957 AK082334 AK158863 BC059868
GenPept AAH59868 BAC30183 BAC38470 BAE34699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca