Version 5.4
Mus musculus Protein: Fip1l1
Summary
InnateDB Protein IDBP-253663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fip1l1
Protein Name FIP1 like 1 (S. cerevisiae)
Synonyms 1300019H17Rik; Rje;
Species Mus musculus
Ensembl Protein ENSMUSP00000109164
InnateDB Gene IDBG-171605 (Fip1l1)
Protein Structure
UniProt Annotation
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006378 mRNA polyadenylation
Cellular Component
GO:0005634 nucleus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Protein Structure and Domains
PDB ID MGI:1914149
InterPro IPR007854 Pre-mRNA polyadenylation factor Fip1
PFAM PF05182
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D824
PhosphoSite PhosphoSite-Q9D824
TrEMBL
UniProt Splice Variant
Entrez Gene 66899
UniGene Mm.448833
RefSeq NP_001153045
MGI ID
MGI Symbol Fip1l1
OMIM
CCDS CCDS51520
HPRD
IMGT
EMBL AK005061 AK008561 AK049672 AK164105 BC003263
GenPept AAH03263 BAB23785 BAB25745 BAC33867 BAE37629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca