InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klf15

Summary

InnateDB Protein

IDBP-253682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klf15

Protein Name

Kruppel-like factor 15

Synonyms

1810013I09Rik; AV048136; AW494632; CKLF; KKLF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109158

InnateDB Gene

IDBG-168952 (Klf15)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300- dependent RELA acetylation (By similarity). Involved in podocyte differentiation. {ECO:0000250, ECO:0000269PubMed:17438289, ECO:0000269PubMed:18586263, ECO:0000269PubMed:20375365, ECO:0000269PubMed:20566642, ECO:0000269PubMed:22367544, ECO:0000269PubMed:22493483, ECO:0000269PubMed:23999430}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in aortic smooth muscle cells. {ECO:0000269PubMed:23999430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010001	glial cell differentiation
GO:0010468	regulation of gene expression
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0015758	glucose transport
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072112	glomerular visceral epithelial cell differentiation
GO:1901653	cellular response to peptide
GO:2000757	negative regulation of peptidyl-lysine acetylation