InnateDB Protein
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IDBP-253793.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rasgrp2
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Protein Name
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RAS, guanyl releasing protein 2
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Synonyms
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Caldaggef1; CDC25L;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109103
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InnateDB Gene
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IDBG-136381 (Rasgrp2)
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Protein Structure
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Function |
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269PubMed:10777492, ECO:0000269PubMed:10913189, ECO:0000269PubMed:11278453, ECO:0000269PubMed:11432821, ECO:0000269PubMed:12239348, ECO:0000269PubMed:15334074, ECO:0000269PubMed:16357324, ECO:0000269PubMed:17492052, ECO:0000269PubMed:9789079}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Enriched at juxtamembrane areas and membrane ruffles. Localizes to the cell bodies and axons of striatal neurons. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in megakaryocytes, platelet and neutrophils but not in lymphocytes (at protein level). Isoform 1 and isoform 3 are detected in brain basal glanglia, heart, lung, spleen, liver and kidney interstitial cells. {ECO:0000269PubMed:10835426, ECO:0000269PubMed:11278453, ECO:0000269PubMed:15334074}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005085
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guanyl-nucleotide exchange factor activity
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GO:0005509
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calcium ion binding
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0043087
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regulation of GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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Cellular Component |
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PDB ID |
MGI:1333849
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InterPro |
IPR000651
Ras-like guanine nucleotide exchange factor, N-terminal
IPR023578
Ras guanine nucleotide exchange factor, domain
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PFAM |
PF00618
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PRINTS |
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PIRSF |
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SMART |
SM00229
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QUG9
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PhosphoSite |
PhosphoSite-Q9QUG9
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TrEMBL |
D3Z3N3
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UniProt Splice Variant |
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Entrez Gene |
19395
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UniGene |
Mm.77017
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RefSeq |
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MGI ID |
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MGI Symbol |
Rasgrp2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC167245
AF081193
AK034683
BC051474
U78171
Y12339
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GenPept |
AAC79697
AAD12742
AAH51474
BAC28797
CAA73008
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