Version 5.4
Mus musculus Protein: Sult1d1
Summary
InnateDB Protein IDBP-254143.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sult1d1
Protein Name sulfotransferase family 1D, member 1
Synonyms 5033411P13Rik; AI987815; ST1d1; SULT-N; Sultn;
Species Mus musculus
Ensembl Protein ENSMUSP00000108940
InnateDB Gene IDBG-176128 (Sult1d1)
Protein Structure
UniProt Annotation
Function Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2- naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. {ECO:0000269PubMed:15087475, ECO:0000269PubMed:18977225, ECO:0000269PubMed:19966186, ECO:0000269PubMed:9647753, ECO:0000269PubMed:9920733}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19966186}.
Disease Associations
Tissue Specificity Detected in kidney and liver. Detected in kidney collecting duct cells. {ECO:0000269PubMed:19966186, ECO:0000269PubMed:9647753}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0000103 sulfate assimilation
GO:0006584 catecholamine metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1926341
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UZZ6
PhosphoSite PhosphoSite-Q3UZZ6
TrEMBL Q8BT67
UniProt Splice Variant
Entrez Gene 53315
UniGene Mm.6824
RefSeq NP_058051
MGI ID 2ZYW
MGI Symbol Sult1d1
OMIM
CCDS CCDS39130
HPRD
IMGT
EMBL AC158917 AF026073 AK017162 AK133530 AK160466 BC066190 U32371
GenPept AAC69919 AAC99889 AAH66190 BAC25504 BAE21709 BAE35805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca