InnateDB Protein
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IDBP-254203.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tfeb
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Protein Name
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transcription factor EB
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Synonyms
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bHLHe35; Tcfeb;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108913
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InnateDB Gene
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IDBG-189516 (Tfeb)
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Protein Structure
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Function |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. {ECO:0000269PubMed:16936731, ECO:0000269PubMed:9806910}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981}. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:16936731}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046982
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protein heterodimerization activity
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103270
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802
Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
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PFAM |
PF00010
PF11851
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R210
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PhosphoSite |
PhosphoSite-Q9R210
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TrEMBL |
Q60982
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UniProt Splice Variant |
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Entrez Gene |
21425
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UniGene |
Mm.2305
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RefSeq |
NP_001155195
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MGI ID |
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MGI Symbol |
Tfeb
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OMIM |
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CCDS |
CCDS50133
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HPRD |
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IMGT |
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EMBL |
AC113536
AC124830
AF079095
U36393
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GenPept |
AAA79697
AAD20979
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