Version 5.4
Mus musculus Protein: Mtmr14
Summary
InnateDB Protein IDBP-254489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mtmr14
Protein Name myotubularin related protein 14
Synonyms 1110061O04Rik; AW553738; C76151;
Species Mus musculus
Ensembl Protein ENSMUSP00000108771
InnateDB Gene IDBG-175845 (Mtmr14)
Protein Structure
UniProt Annotation
Function Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. {ECO:0000250}.
Subcellular Localization Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0001726 ruffle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1916075
InterPro IPR029021 Protein-tyrosine phosphatase-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VEL2
PhosphoSite PhosphoSite-Q8VEL2
TrEMBL Q3TTC5
UniProt Splice Variant
Entrez Gene 97287
UniGene Mm.197816
RefSeq NP_081125
MGI ID
MGI Symbol Mtmr14
OMIM
CCDS CCDS20412
HPRD
IMGT
EMBL AK161445 BC018294
GenPept AAH18294 BAE36400

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca