InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gprasp1

Summary

InnateDB Protein

IDBP-254513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gprasp1

Protein Name

G protein-coupled receptor associated sorting protein 1

Synonyms

2210415K24Rik; 3110031O14Rik; C87852; GASP; GASP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108769

InnateDB Gene

IDBG-172647 (Gprasp1)

Protein Structure

UniProt Annotation

Function

Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2. {ECO:0000269PubMed:23954414}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain, with higher expression in the hippocampus, hypothalamus and olfactory bulb. {ECO:0000269PubMed:15086532}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0008333	endosome to lysosome transport
GO:1990172	G-protein coupled receptor catabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1917418

InterPro

IPR006911 Armadillo repeat-containing domain
IPR016024 Armadillo-type fold

PFAM

PF04826

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5U4C1

PhosphoSite

PhosphoSite-Q5U4C1

TrEMBL

UniProt Splice Variant

Entrez Gene

67298

UniGene

Mm.475515

RefSeq

NP_080357

MGI ID

MGI Symbol

Gprasp1

OMIM

CCDS

CCDS30409

HPRD

IMGT

EMBL

AB093241 AK039156 AK050919 AK083192 AL683822 BC027187 BC085157

GenPept

AAH27187 AAH85157 BAC30259 BAC34459 BAC38803 BAC41425 CAM27375