InnateDB Protein
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IDBP-254595.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Morf4l2
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Protein Name
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mortality factor 4 like 2
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Synonyms
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2410017O14Rik; mKIAA0026; Mrgx; Sid393p;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108722
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InnateDB Gene
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IDBG-173249 (Morf4l2)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00972}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
47 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927167
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InterPro |
IPR016197
Chromo domain-like
IPR026541
MRG domain
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PFAM |
PF05712
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9R0Q4
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PhosphoSite |
PhosphoSite-Q9R0Q4
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TrEMBL |
A2AEB8
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UniProt Splice Variant |
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Entrez Gene |
56397
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UniGene |
Mm.428261
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RefSeq |
NP_001161698
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MGI ID |
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MGI Symbol |
Morf4l2
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OMIM |
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CCDS |
CCDS30422
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HPRD |
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IMGT |
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EMBL |
AB025049
AK075946
AK088849
AK089963
AK129038
AK131944
AK145686
AK150401
AK150670
AK151570
AK160012
AK161610
AK164433
AK166637
AL671887
BC075653
BC088731
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GenPept |
AAH75653
AAH88731
BAA84687
BAC36075
BAC40611
BAC41017
BAC97848
BAE20890
BAE26588
BAE29527
BAE29752
BAE30512
BAE35559
BAE36491
BAE37786
BAE38909
CAM17215
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