Version 5.4
Homo sapiens Protein: ARHGEF40
Summary
InnateDB Protein IDBP-2546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF40
Protein Name Rho guanine nucleotide exchange factor (GEF) 40
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298694
InnateDB Gene IDBG-2544 (ARHGEF40)
Protein Structure
UniProt Annotation
Function May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16143467}. Note=Concentrated in the perinuclear region.
Disease Associations
Tissue Specificity Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level). {ECO:0000269PubMed:16143467}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TER5
PhosphoSite PhosphoSite-Q8TER5
TrEMBL
UniProt Splice Variant
Entrez Gene 55701
UniGene Hs.733352
RefSeq NP_060541
HUGO HGNC:25516
OMIM 610018
CCDS CCDS32041
HPRD 13335
IMGT
EMBL AK001219 AK024463 AK074057 AL137291 AL161668 BC000084 BC142692
GenPept AAH00084 AAI42693 BAA91563 BAB15753 BAB84883 CAB70682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca