InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dab2ip

Summary

InnateDB Protein

IDBP-254810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dab2ip

Protein Name

disabled homolog 2 (Drosophila) interacting protein

Synonyms

2310011D08Rik; AI480459; Aip1; mKIAA1743;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108610

InnateDB Gene

IDBG-164698 (Dab2ip)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0032403	protein complex binding
GO:0035591	signaling adaptor activity
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042803	protein homodimerization activity
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0047485	protein N-terminus binding
GO:0051721	protein phosphatase 2A binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000185	activation of MAPKKK activity
GO:0001525	angiogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0006986	response to unfolded protein
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007252	I-kappaB phosphorylation
GO:0007257	activation of JUN kinase activity
GO:0008285	negative regulation of cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010596	negative regulation of endothelial cell migration
GO:0010633	negative regulation of epithelial cell migration
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010976	positive regulation of neuron projection development
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525	negative regulation of angiogenesis
GO:0021814	cell motility involved in cerebral cortex radial glia guided migration
GO:0021819	layer formation in cerebral cortex
GO:0030308	negative regulation of cell growth
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032312	regulation of ARF GTPase activity
GO:0032320	positive regulation of Ras GTPase activity
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0034260	negative regulation of GTPase activity
GO:0034261	negative regulation of Ras GTPase activity
GO:0035148	tube formation
GO:0035414	negative regulation of catenin import into nucleus
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254	regulation of protein complex assembly
GO:0043407	negative regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity
GO:0044257	cellular protein catabolic process
GO:0045087	innate immune response
GO:0045732	positive regulation of protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048147	negative regulation of fibroblast proliferation
GO:0048812	neuron projection morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070317	negative regulation of G0 to G1 transition
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071158	positive regulation of cell cycle arrest
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090129	positive regulation of synapse maturation
GO:1900006	positive regulation of dendrite development
GO:1900744	regulation of p38MAPK cascade
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
GO:1901800	positive regulation of proteasomal protein catabolic process
GO:2000599	negative regulation of cyclin catabolic process
GO:2001224	positive regulation of neuron migration
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0032809	neuronal cell body membrane
GO:0043025	neuronal cell body
GO:0044300	cerebellar mossy fiber
GO:0044301	climbing fiber
GO:1990032	parallel fiber

Protein Structure and Domains

PDB ID

MGI:1916851

InterPro

IPR000008 C2 domain
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR021887 Protein of unknown function DUF3498

PFAM

PF00168
PF00169
PF00616
PF12004

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt