InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsc22d3

Summary

InnateDB Protein

IDBP-254825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsc22d3

Protein Name

TSC22 domain family, member 3

Synonyms

DIP; Dsip1; Gilz; Tilz3; TSC-22R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108620

InnateDB Gene

IDBG-174941 (Tsc22d3)

Protein Structure

UniProt Annotation

Function

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250, ECO:0000269PubMed:20124407}.

Subcellular Localization

Isoform 1: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus.Isoform 4: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 4 localizes to the cytoplasm, but in differentiating myoblasts, isoform 4 is localized to the nucleus.

Disease Associations

Tissue Specificity

Constitutively expressed in lung, intestine, kidney and liver, most probably by resident cells from the macrophage lineage. Expression inversely correlates with T-cell activation, being higher in resting cells and lower in cells activated by TCR/CD3 triggering. Isoform 1 and isoform 4 are expressed in spleen and skeletal muscle (at protein level). Isoform 1 is expressed in thymus, lymph nodes, bone marrow, spleen, lung and skeletal muscle. {ECO:0000269PubMed:11468175, ECO:0000269PubMed:12393603, ECO:0000269PubMed:20124407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043426	MRF binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006970	response to osmotic stress
GO:0007589	body fluid secretion
GO:0045087	innate immune response (InnateDB)
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0070236	negative regulation of activation-induced cell death of T cells