Version 5.4
Mus musculus Protein: Ms4a3
Summary
InnateDB Protein IDBP-254841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ms4a3
Protein Name membrane-spanning 4-domains, subfamily A, member 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000108608
InnateDB Gene IDBG-146841 (Ms4a3)
Protein Structure
UniProt Annotation
Function Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2158468
InterPro IPR007237 CD20-like
PFAM PF04103
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920C4
PhosphoSite PhosphoSite-
TrEMBL Q53ZU3
UniProt Splice Variant
Entrez Gene 170813
UniGene
RefSeq NP_573509
MGI ID
MGI Symbol Ms4a3
OMIM
CCDS CCDS29605
HPRD
IMGT
EMBL AF280401 AF321128 AK036464 AY258288 BC117013 BC117015 CH466534
GenPept AAI17014 AAI17016 AAK37993 AAL16955 AAP14647 BAC29440 EDL41434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca