Version 5.4
Mus musculus Protein: Tmem146
Summary
InnateDB Protein IDBP-254845.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem146
Protein Name transmembrane protein 146
Synonyms 4921529N20Rik; 4933402B14Rik; 619718; AW045609; Gm6095; Tmem146;
Species Mus musculus
Ensembl Protein ENSMUSP00000108603
InnateDB Gene IDBG-192747 (Tmem146)
Protein Structure
UniProt Annotation
Function Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. {ECO:0000269PubMed:21224844}.
Subcellular Localization Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:21224844}; Single-pass type I membrane protein {ECO:0000269PubMed:21224844}. Note=Specifically located in the principal piece of sperm tail.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:21224844}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030317 sperm motility
GO:0048240 sperm capacitation
Cellular Component
GO:0036128 CatSper complex
GO:0097228 sperm principal piece
Protein Structure and Domains
PDB ID MGI:2147030
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E9Q9F6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 106757
UniGene Mm.23401
RefSeq NP_780559
MGI ID
MGI Symbol Catsperd
OMIM
CCDS CCDS50153
HPRD
IMGT
EMBL AK077082 BC115864 BC116633 CH466537 CT010491 CT485788 HQ441159 HQ441160
GenPept AAI15865 AAI16634 ADU32560 ADU32561 BAC36602 EDL38183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca