Version 5.4
Mus musculus Protein: Lhx6
Summary
InnateDB Protein IDBP-254872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx6
Protein Name LIM homeobox protein 6
Synonyms Lhx6.1;
Species Mus musculus
Ensembl Protein ENSMUSP00000108587
InnateDB Gene IDBG-164971 (Lhx6)
Protein Structure
UniProt Annotation
Function Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. {ECO:0000269PubMed:10393337, ECO:0000269PubMed:15201337, ECO:0000269PubMed:17376969, ECO:0000269PubMed:18339674, ECO:0000269PubMed:18613121}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Brain specific. Expressed by neurons in the amygdala that are activated by reproductive olfactory stimuli and project in regions of the hypothalamus involved in reproduction (at protein level). {ECO:0000269PubMed:10393337, ECO:0000269PubMed:15944132}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021877 forebrain neuron fate commitment
GO:0021884 forebrain neuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1306803
InterPro IPR001356 Homeobox domain
IPR001781 Zinc finger, LIM-type
IPR009057 Homeodomain-like
PFAM PF00046
PF00412
PRINTS
PIRSF
SMART SM00389
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R1R0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16874
UniGene Mm.12881
RefSeq
MGI ID
MGI Symbol Lhx6
OMIM
CCDS CCDS38113
HPRD
IMGT
EMBL AB031039 AB031040 AJ000337 AL773525 BC065077
GenPept AAH65077 BAA83420 BAA83421 CAA04011 CAM16137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca