InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hpse

Summary

InnateDB Protein

IDBP-254998.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Hpse

Protein Name

heparanase

Synonyms

Hpa; Hpr1; HSE1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108529

InnateDB Gene

IDBG-183400 (Hpse)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0030305	heparanase activity
GO:0045545	syndecan binding
GO:0046983	protein dimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007160	cell-matrix adhesion
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030194	positive regulation of blood coagulation
GO:0030200	heparan sulfate proteoglycan catabolic process
GO:0033690	positive regulation of osteoblast proliferation
GO:0051797	regulation of hair follicle development
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005764	lysosome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1343124

InterPro

IPR005199 Glycoside hydrolase, family 79
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF03662

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z3C3

UniProt Splice Variant

Entrez Gene

15442

UniGene

Mm.265786

RefSeq

MGI ID

MGI Symbol

Hpse

OMIM

CCDS

HPRD

IMGT

EMBL

AC161510

GenPept