InnateDB Protein
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IDBP-255050.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Chrdl1
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Protein Name
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chordin-like 1
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Synonyms
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CHL; CHL1; Nrln1; VOPT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108499
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InnateDB Gene
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IDBG-176721 (Chrdl1)
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Protein Structure
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Function |
Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, lung, liver, kidney and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1933172
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InterPro |
IPR001007
von Willebrand factor, type C
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PFAM |
PF00093
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PRINTS |
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PIRSF |
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SMART |
SM00214
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TIGRFAMs |
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Modification |
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SwissProt |
Q920C1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83453
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UniGene |
Mm.485673
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RefSeq |
NP_001107857
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MGI ID |
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MGI Symbol |
Chrdl1
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OMIM |
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CCDS |
CCDS53208
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HPRD |
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IMGT |
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EMBL |
AF296451
AF305714
AF321853
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GenPept |
AAG27460
AAK71523
AAK95586
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