InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1c

Summary

InnateDB Protein

IDBP-255162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1c

Protein Name

calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonyms

Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108444

InnateDB Gene

IDBG-182003 (Cacna1c)

Protein Structure

UniProt Annotation

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}. Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in heart, followed by brain and spinal cord. Expressed in retina in rod bipolar cells. {ECO:0000269PubMed:18586882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007268	synaptic transmission
GO:0007628	adult walking behavior
GO:0008217	regulation of blood pressure
GO:0008542	visual learning
GO:0017156	calcium ion-dependent exocytosis
GO:0019229	regulation of vasoconstriction
GO:0030073	insulin secretion
GO:0030252	growth hormone secretion
GO:0034765	regulation of ion transmembrane transport
GO:0042593	glucose homeostasis
GO:0046620	regulation of organ growth
GO:0055085	transmembrane transport
GO:0060083	smooth muscle contraction involved in micturition
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0002095	caveolar macromolecular signaling complex
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:103013

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01630
PR01635

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt