InnateDB Protein
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IDBP-255344.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Spp1
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Protein Name
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secreted phosphoprotein 1
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Synonyms
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2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1; OP; Opn; Opnl; Ric; Spp-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108368
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InnateDB Gene
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IDBG-185485 (Spp1)
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Protein Structure
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Function |
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
76 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98389
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InterPro |
IPR002038
Osteopontin
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PFAM |
PF00865
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PRINTS |
PR00216
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PIRSF |
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SMART |
SM00017
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TIGRFAMs |
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Modification |
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SwissProt |
P10923
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PhosphoSite |
PhosphoSite-P10923
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TrEMBL |
Q547B5
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UniProt Splice Variant |
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Entrez Gene |
20750
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UniGene |
Mm.470561
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RefSeq |
NP_001191131
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MGI ID |
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MGI Symbol |
Spp1
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OMIM |
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CCDS |
CCDS19486
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HPRD |
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IMGT |
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EMBL |
AC124106
AF515708
AK149588
AK150819
AK151069
AK151562
AK154908
AK160540
AK171158
BC014284
BC057858
CH466529
CT010357
J04806
X13986
X16151
X51834
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GenPept |
AAA57265
AAH14284
AAH57858
AAM53974
BAE28978
BAE29882
BAE30085
BAE30504
BAE32918
BAE35857
BAE42282
CAA32165
CAA34276
CAA36132
CAJ18565
EDL20221
EDL20222
EDL20225
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