InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epb4.1l3

Summary

InnateDB Protein

IDBP-255496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epb4.1l3

Protein Name

erythrocyte protein band 4.1-like 3

Synonyms

4.1B; Dal1; DAL1P; Epb41l3; NBL3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108300

InnateDB Gene

IDBG-196143 (Epb4.1l3)

Protein Structure

UniProt Annotation

Function

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269PubMed:10652311}; Peripheral membrane protein {ECO:0000269PubMed:10652311}; Cytoplasmic side {ECO:0000269PubMed:10652311}. Cytoplasm {ECO:0000250}. Cell junction {ECO:0000269PubMed:10652311}. Note=Detected in the cytoplasm of actively dividing cells.

Disease Associations

Tissue Specificity

Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expressed in kidney but also in heart and brain. Isoform 6 seems to be most abundant in kidney while isoform 4 and isoform 5 are predominantly expressed in heart and brain. {ECO:0000269PubMed:10652311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0006915	apoptotic process
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0008360	regulation of cell shape
GO:0030865	cortical cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization
GO:0030913	paranodal junction assembly
GO:0043217	myelin maintenance
GO:0048812	neuron projection morphogenesis
GO:0071205	protein localization to juxtaparanode region of axon
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0019898	extrinsic component of membrane
GO:0030673	axolemma
GO:0033270	paranode region of axon
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

MGI:103008

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR007477 SAB domain
IPR008379 Band 4.1, C-terminal
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR021187 Band 4.1 protein
IPR029071 Ubiquitin-related domain

PFAM

PF04382
PF05902
PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002304

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WV92

PhosphoSite

PhosphoSite-Q9WV92

TrEMBL

UniProt Splice Variant

Entrez Gene

13823

UniGene

Mm.408629

RefSeq

MGI ID

MGI Symbol

Epb4.1l3

OMIM

CCDS

HPRD

IMGT

EMBL

AF152247 AF177146 AK173080

GenPept

AAD38048 AAD51365 BAD32358